Inflammatory mediators have an established role in inducing insulin resistance and promoting hyperglycemia. In turn, hyperglycemia has been argued to drive immune cell dysfunction as a result of mitochondrial dysfunction. Here, the authors review the evidence challenging this view. First, it is pointed out that inflammatory mediators are known to induce altered mitochondrial function. In this regard, critical care patients suffer both an elevated inflammatory tone as well as hyperglycemia, rendering it difficult to distinguish between the effects of inflammation and (...) hyperglycemia. Second, emerging evidence indicates that a decrease in mitochondrial respiration and an increase in reactive oxygen species (ROS) production are not necessarily manifestations of pathology, but adaptations taking shape as the mitochondria is abdicating its adenosine triphosphate (ATP)‐producing function (which is taken over by glycolysis) and instead becomes “retooled” for an immunological role. Collectively, these observations challenge the commonly held belief that acute hyperglycemia induces mitochondrial damage leading to immune cell dysfunction. (shrink)

1. In his paper “On Denoting” Russell points out what he calls a puzzle every satisfactory theory of denoting will have to solve. Of the three sentences George IV. wished to know whether Scott was the author of WaverleyScott is the author of WaverleyGeorge IV. wished to know whether Scott was Scott the first two, and, are presumably true, while the third,, is presumably false. The reason given for considering this arrangement of truth values a puzzle is that the ‘is’ (...) in signifies identity; that the proper name ‘Scott’ and the descriptive phrase ‘the author of Waverley’ denote the same object; and that, therefore, if the latter is replaced by the former in the true sentence, the resulting sentence,, should again be true. Yet is false, or, as one also says, the context considered is nonextensional with respect to this replacement. (shrink)

This book approaches Hegel from the standpoint of what we might call the question of knowledge. Hegel, of course, had no "theory of knowledge" in the narrow and abstract sense in which it has come to be understood since Locke and Kant. "The examination of knowledge," he holds, "can only be carried out by an act of knowledge," and "to seek to know before we know is as absurd as the wise resolution of Scholasticus, not to venture into the water (...) until he had learned to swim. " * While Hegel wrote no treatise exclusively devoted to epistemology, his entire philosophy is nonetheless a many-faceted theory of truth, and thus our title - Beyond Epistemology - is meant to suggest a return to the classical meaning and relation of the terms episteme and logos. I had originally planned to include a lengthy introduction for these essays, setting out Hegel's general view of philosophic truth. But as the papers came in, it became clear that I had chosen my contributors too well; indeed, they have all but put me out of business. In any case, it gives me great pleasure to have been able to gather this symposium of outstanding Hegel scholars, to provide for them a forum on a common theme of great importance, and especially, thanks to Arnold Miller, to have Hegel himself among them. Frederick G. Weiss Charlottesville, Va. • The Logic of Hegel, trans. from the Etu;yclopaedta by William Wallace. 2nd ed. (shrink)

Die Homerische Odyssee in der ursprünglichen Sprachform wiederhergestellt von August Fick. Göttingen, 1883.Die Homerische Ilias nach ihrer Entstehung betrachtet wad in der ursprünglichen Sprach-form wiederliergestellt von August Fick. Göttingen, 1885–1886.Philologus, xliii. 1. Dr. K. Sittl, ‘Die Äolismen der Hornerischen Sprache.’ ‘Herr Dr. Karl Sittl und die Hornerischen Äolismen’ von DR. Gustav Hinrichs. Berlin, 1884.Bezzenberger's Beiträge zur Kunde der Indogerm. Sprachen. Vol. xi. ‘Die Sprachform der altionischen und altattischen Lyrik.’ A. Fick.

Die neue Edition der Vorlesungen über die 'Philosophie der Weltgeschichte' stellt den Versuch dar, eine einzige der gehaltenen Vorlesungen aus drei Manuskripten unterschiedlicher Qualität möglichst authentisch zu rekonstruieren und bietet somit erst die Möglichkeit, sich wissenschaftlich mit der systematischen Konzeption der Hegelschen Geschichtsphilosophie zu beschäftigen. Der Band enthält zusätzlich einen umfangreichen Anmerkungsteil über die orientalische Welt, in dem ausführlich die zum großen Teil schwer zugänglichen Quellen nachgewiesen worden sind, die Hegel als Material für seine Vorlesung benutzt hat.

On s’interroge, dans ce livre, sur la façon dont les peuples sont représentés : question indissolublement esthétique et politique. Les peuples aujourd’hui semblent exposés plus qu’ils ne l’ont jamais été. Ils sont, en réalité, sous-exposés dans l’ombre de leurs mises sous censure ou – pour un résultat d’invisibilité équivalent – sur-exposés dans la lumière artificielle de leurs mises en spectacle. Bref ils sont, comme trop souvent, exposés à disparaître. À partir des exigences formulées par Walter Benjamin (une histoire ne vaut (...) que si elle donne voix aux « sans noms ») ou par Hannah Arendt (une politique ne vaut que si elle fait surgir ne fût-ce qu’une « parcelle d’humanité »), on interroge ici les conditions d’une possible représentation des peuples. Cela passe moins par l’histoire du portrait de groupe hollandais et des « portraits de troupes » totalitaires que par l’attention spécifique accordée aux « petits peuples » par les poètes (Villon, Hugo, Baudelaire par exemple), les peintres (Rembrandt, Goya ou Gustave Courbet), les photographes (Walker Evans, August Sander ou, pour un exemple contemporain, Philippe Bazin). Le cinéma, quant à lui, nomme figurants ces « petits peuples » devant lesquels agissent et s’agitent les « acteurs principaux », les stars comme on dit. D’où que les figurants incarnent un enjeu crucial, historique et politique, du cinéma lui-même, depuis sa naissance – La Sortie des usines Lumière – jusqu’à ses élaborations modernes chez Eisenstein et Rossellini, et bien au-delà encore. Une longue analyse est ici consacrée au travail de Pier Paolo Pasolini, à sa façon de retrouver les « peuples perdus » dans leurs « gestes survivants », selon un processus que permettent d’éclairer les analyses d’Erich Auerbach (pour les formes poétiques), d’Aby Warburg (pour les formes visuelles) et d’Ernesto De Martino (pour les formes sociales). Sans oublier quelques exemples plus contemporains, tel que le film du Chinois Wang Bing intitulé, précisément, L’Homme sans nom. (shrink)

Global Economy, Global Justice explores a vital question that is suppressed in most economics texts: "what makes for a good economic outcome?" Neoclassical theory embraces the normative perspective of "welfarism" to assess economic outcomes. This volume demonstrates the fatal flaws of this perspective--flaws that stem from objectionable assumptions about human nature, society and science. Exposing these failures, the book obliterates the ethical foundations of global neoliberalism. George DeMartino probes heterodox economic traditions and philosophy in search of an ethically viable alternative (...) to welfarism. Drawing on the work of Amartya Sen, DeMartino proposes the egalitarian principle of the "global harmonization of capabilities" to guide economics. This principle provides a basis for resisting oppression the world over while nevertheless demanding respect for cultural diversity. DeMartino puts this principle to work adjudicating contemporary debates over global policy regimes, and completes thebook with a set of deeply egalitarian global policies for the year 2025. Global Economy, Global Justice 's engaging prose will appeal to those seeking to understand the intersection between economics and political philosophy. Its focus on the normative foundations of contemporary policy disputes makes it unique in the literature on globalization. (shrink)

Written in the 1960s, TRUTH AND METHOD is Gadamer's magnum opus.

George Berkeley (1685-1753) is the superstar of Irish Philosophy. He entered Trinity College, Dublin, in 1700 and became a fellow in 1707. In 1724 he resigned his Fellowship to become Dean of Derry, and in 1734 he was made Bishop of Cloyne. He settled in Oxford in 1752 and died the following year. The work of George Berkeley is marked by its diversity and range. His writings take in such topics as mathematics, psychology, politics, health, economics, deism and education, as (...) well as that with which he is most associated - philosophy. Whatever topic he dealt with, his grasp of the subject matter was always impressive and his criticisms of his contemporaries often acute. Among the most noteable of the British Empiricists, he took his starting point from Locke's new 'way of ideas', but he rejected abstract ideas and the possibility of real existence outside perception. It is for this doctrine that he is most known - that there is no such thing as matter, and that things are collections of ideas which can exist only in our minds and only for so long as they are perceived. This philosophy, summed up in his phrase 'to be is to be perceived', he termed 'immaterialism'. A.C. Fraser's collection includes a series of what were previously unpublished notes by Berkeley on all the main topics of his philosophy. This, the 1901 edition, was the first complete edition of his works. (shrink)

A brilliant and comprehensive history of the creation of the modern Western mind. Soul Machine takes us back to the origins of modernity, a time when a crisis in religious authority and the scientific revolution led to searching questions about the nature of human inner life. This is the story of how a new concept—the mind—emerged as a potential solution, one that was part soul and part machine, but fully neither. In this groundbreaking work, award-winning historian George Makari shows how (...) writers, philosophers, physicians, and anatomists worked to construct notions of the mind as not an ethereal thing, but a natural one. From the ascent of Oliver Cromwell to the fall of Napoleon, seminal thinkers like Hobbes, Locke, Diderot, and Kant worked alongside often-forgotten brain specialists, physiologists, and alienists in the hopes of mapping the inner world. Conducted in a cauldron of political turmoil, these frequently shocking, always embattled efforts would give rise to psychiatry, mind sciences such as phrenology, and radically new visions of the self. Further, they would be crucial to the establishment of secular ethics and political liberalism. Boldly original, wide-ranging, and brilliantly synthetic, Soul Machine gives us a masterful, new account of the making of the modern Western mind. (shrink)

Throughout The Blessed and Boundless God, he proves his doctrine by demonstrating God's incomparableness in His being, attributes, works, and words. Swinnock is a pastor-theologian who views theology as the means by which we grow in acquaintance with God and, consequently, in godliness.

Neopublikovannye raboty G.G. Shpeta -- Opublikovannye statʹi G.G. Shpeta.